Question

Describe the intracellular events that occur in a neuron once an action potential reaches a synaptic end bulb.

Answer 1

• Once the action potential reaches the synaptic end bulb.
• The action potential cause the depolarizatiom of the membrane.
• Due to the depolarizatiom the voltage-gated sodium channels are opened and sodium enters to the cell.
• Then the further depolarizatiom occurs on the membrane.
• Which cause the opening of calcium channels, calcium ions enters to the cell and initiates the signalling processes.
• Calcium will interact with SNARE protein within the synapse.
• These interactions between the SNARE protein causes the membrane fusion. The synaptic end bulb or synaptic vesicle fused with axon terminal.
• This fusion cause the release of neurotransmitters to the synaptic cleft.