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pharmacology question What makes the amount of renin released in the body the major determinant of...

pharmacology question

What makes the amount of renin released in the body the major determinant of the rate of angiotensin II production and not the levels of angiotensinogen?

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  • Angiotensinogen is a precursor for a peptide hormone angiotensin. It is produced by the liver.
  • When renin is released from macula densa cells of the juxtaglomerular apparatus, it converts angiotensinogen into angiotensin-I.
  • Angiotensin convertin enzyme present in lung capillaries helps in conversion of angiotensin-I into angiotensin-II.

As renin do not affect the amount of angiotensinogen produced by liver but, it promotes production of angiotensin-I and eventually angiotensin-Il, renin is a major determinant of the rate of angiotensin II production.

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