Question

How does Narcan and Suboxone work to reduce the impact of opioids in the body as antagonist at the Mu receptor. What part components of the plasma membrane participate. How is glycogen working in this situation?

Answer 1

Narcan and Suboxone are the drugs used parenterally to reduce pain, impact of opioids such as(Narcotics)  and addiction of such drugs.Suboxone/Buprenorphine being a Mu receptor antagonist partially activate opiate receptors.Its acts on CNS and has a higher affinity to binds to the Mu-opioid receptors and slows the dissociation kinetics and it also reduces the withdrawal syymptoms.

Plasma membrane participates in the absorption of the drug (sub-lingual).The lipid component of target cell membrane identifies the cyclotids bound to the cells and extend the activity and these cyclotids induce disruption of membrane by a pore formation mechanism which helps in the absorption.

Glycogen synthesis is depleted by these drug and it reduce the glycogen content by 60% of the initial amount.