Explain cellular mechanotransduction including key structures/proteins. (6 mins)
ANSWER: Mechanotransduction is any of various mechanism by which the cells convert mechanical stimulus into electrochemical activity. This form of transduction is important in proprioception, touch, balance and hearing. For this process to take place, a mechanically gated ion channel which gets stimulated and opens and produce a transduction current that changes the membrane potential of the cell. One such mechanism is seen in the ear where the opening of ion channel in the hair cells of the cochlea in the inner ear. Cardiomyocytes are composed of several subcompartments in mechanotransduction,which include the contractile sarcomeres, cytoskeletal filament networks.
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