Which one of the following statements is FALSE?
a. Diabetes insipidus can be caused by an over production of vasopressinase by mothers.
b. A more permeable collecting duct results in more concentrated urine.
c. Nephrogenic diabetes insipidus is characterized by reduced production of ADH.
d. Increased ADH results in more aquaporins in the collecting ducts.
e. Diuresis is a response to hypervolemia.
C) Nephrogenic diabetes insipidus is characterized by reduced production of ADH
Explanation :
Increased ADH causes increased number of aquaporins in the collecting ducts causing increased absorption of water.
When blood volume is high, ADH secretion is inhibited and as a result large volume of urine is formed so called diuresis.
Nephrogenic diabetes insipidus (NDI) is an inability to concentrate urine due to impaired renal tubule response to vasopressin (ADH), which leads to excretion of large amounts of dilute urine. Vasopressin level is high but the renal tubules showing resistance to it.
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