Question

Describe the effects of the following mutations on skeletal muscle structure and/or function. Explain your answer...

Describe the effects of the following mutations on skeletal muscle structure and/or function. Explain your answer in a sentence or two.:

  1. Troponin that could not bind calcium.
  1. Defective titin
  1. Myosin II that could not be phosphorylated.
Science   Anatomy-And-Physiology   
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Answer #1

1 . If troponin is unable to bind to calcium, it won't undergo conformational changes to expose sites for myosin binding and hence there would be not be any cross bridge formation nor muscle contraction.

2. defective titin would lead to instability of thick filaments as well as disturbed sarcomere structure maintenance during muscle streching.

3. incase myosin II is not phosphorylated, it would affect the maintenance of stress fibres as well as assembly and contraction of myosin II.

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