Question

QUESTION 9 Gastric acid (select the BEST CORRECT statement)

Pepsinogen autocatalyzes the enzymatic cleavage of an inhibitory 44 amino acid peptide, a reaction that is optimal in the high pH environment of the stomach lumen.

Endocrine cells of the duodenum release secretin, a peptide hormone that causes endocrine cells of the pancreas to secrete bicarbonate.

A drug that inhibits the H+/K+-ATPase pump on the surface of gastric parietal cells would also indirectly inhibit the activity of pepsin.

All of the above are correct Only (a) and (b) are correct

Answer 1

All of the above are correct

The chief cells of stoamch produces pepsinogen get converted into active pepsin digestive enzyme when the parietal cells produced the HCl and provides acidic environment to pepsinogen.The pepsinogen autocatalyzes the enzymatic cleavage of an inhibitory 44 amino acid peptide which is optimal in lower acidic environement or higher pH.

Secretin released by the intestinal lumen or to the bloodstream and interacts with pancreatic ductal cells to stimulate the bicarbonate secretion which helps in neutralizing the pH of the chyme entering in small intestine.

The inhibition of H+/K+-ATPase pump on the surface of gastric parietal cells , reduces the acidification of the stomach , which will inhibit the pepsinogen conversion to pepsin.