Question

Which of these occur as a result of insulin signaling in a normal (healthy) individual? Select correct answers:

a. Synthesis of glycogen

b. Increased breakdown of glucose by glycolysis (in the liver, not muscle)

c. Increased fatty acid synthesis

d. Increased secretion of glucose by the liver

e. Translocation of GLUT4 transporter to the cell surface

Answer 1

a. Synthesis of glycogen

c. Increased fatty acid synthesis

b. Increased breakdown of glucose by glycolysis (in the liver, not muscle)

e. Translocation of GLUT4 transporter to the cell surface

Explanation:  Insulin stimulates glycolysis and lipogenesis, but suppresses gluconeogenesis in the liver.

Insulin stimulates the liver to store glucose in the form of glycogen. A large fraction of glucose absorbed from the small intestine is immediately taken up by hepatocytes, which convert it into the storage polymer glycogen. Insulin has several effects in liver which stimulate glycogen synthesis.

Insulin increase glucos eintake by the cells by up regualting the GLUT4 transporter