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Draw or describe two pathways by which an individual can develop intermediate or ambiguous genitalia.

Draw or describe two pathways by which an individual can develop intermediate or ambiguous genitalia.

Science   Anatomy-And-Physiology   
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Answer #1

The two pathways by which an individual can develop intermediate or ambiguous genitalia.

  • XY -> Functional SRY gene -> Testes determining factor produced -> Testes develop -> Woflian ducts develop into male reproductive tract -> non-functional 5 alpha reductase -> testosterone is not converted to DHT -> External genitalia can appear female or ambiguous
  • XX -> no SRY gene -> no testes determining factor or antimullerian hormone -> mullerian tubes differentiate into uterine tubes, uterus, upper 1/3 of birth canal -> hormoneally atypical -> adrenal glands over produce androgens -> congenital adrenal hyperplasia -> genitalia are intermediate.
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