Question

Which condition results in metabolic acidosis with severe hypokalemia and chronic alkaline urine?

1. Renal tubular acidosis-

2. Phenformin-induced acidosis

3. Acidosis caused by starvation

4. Diabetic ketoacidosis

Answer 1

The condition is RTA - Renal tubular acidosis.

Renal tubular acidosis is a condition results in metabolic acidosis  with severe severe hypokalemia and chronic alkaline urine.

There are four types of RTA ( Renal tubular acidosis) - 1. Distal RTA.

2. Proximal RTA.

3. Mixed RTA.

4. Hyporenemic hypoaldosteronism RTA.

It is mainly due to the failure of secretion of H+ ions and unable to acidify the urine.There also loss of bicarbonate ions HCO3- resulting in metabolic acidosis, hypolalemia and chronic alkaline urine.

This alkaline urine may leads to formation of stones in urinary tract.