In older men, what is the pathophysiological basis for the decline in levels of testosterone caused by andropause?
Although the exact reason of age related male andropause is not well established, some possible pathology may be as follows:
- Decreased rate of production by testes due to reduction in size and weight of testes with age.
- increased level of stress, genetic and metabolic disorders, testicular trauma and some critical illness.
- Chronic illness, some particular medication and chronic substance use may also be the reason.
- Obesity, malnutrition, physical stress and previous surgery.
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