Blood Rh typing incompatibility arises when there is a mismatch between maternaland fetal Rh factor that could cause development of antibodies against the fetal blood cells. This condition is usually harmless until the mother's second pregnancy or “sensitized" . This is the reason behind the Donna's miscarriage of second pregnancy. When Donna who is A-ve group carrying one another Rh-positive child, Donna's own antibodies consider the the Rh proteins on the surface of the fetal blood cells as foreign and attack those cells by passing the antibodies via placental bloodstream.
It leads to various complications including erythroblastosis fetalis. It is a hemolytic anemia due to transplacental transmission of maternal antibodies to RBCs of fetus.
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