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why does fatigue from myasthenia gravis become more prominent at night?

why does fatigue from myasthenia gravis become more prominent at night?

Science   Anatomy-And-Physiology   
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Answer #1

Fatigue from MYASTHENIA GRAVIS is prominent at night as a result of

  1. The number of receptors for the stimulation of muscle for movement and daily activity is less in patients with myasthenia gravis. So as a result the same receptors are stimulated over and over for the activities that we have to do during day time . This results in the fatigue of the receptor and as a result the symptoms increase
  2. The amount of acetylcholine has to be high to produce effect on the muscle as the receptors are low . So when high amount of acetylcholine produced the whole day without rest result in depletion in acetylcholine neurotransmitter.
  3. Respiratory systems stoping for few seconds can occur in sleep which results in lack of O2 and accumulation of lactic acid result in more fatigue at night
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