Question

Binding of glucagon to its receptor directly leads to… Inactivation of a G protein [definitely not]...

  1. Binding of glucagon to its receptor directly leads to…

    1. Inactivation of a G protein [definitely not]

    2. Activation of Protein Kinase B (PKB)

    3. Phosphorylation of glycogen synthase [other group changed]

    4. Translocation of glucose transporters to the cell membrane

    5. Transcription of glycolytic enzymes

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Answer #1

E) Transcription of glycolytic enzymes

Explanation: The glucagon signaling pathway is initiated by binding to specific receptors on the target cell membrane, which activates adenylate cyclase by Gs protein, catalyzing the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP), thereby increasing intracellular cAMP levels. cAMP causes activation of protein kinase A PKA.

cAMP also activates phosphorylase kinase, which then phosphorylates glycogen phosphorylase b (PYG b), converting it into the active form called phosphorylase a. Phosphorylase a is the enzyme responsible for the release of glucose 1-phosphate from glycogen polymers.

cAMP binds to protein kinase A, and the complex phosphorylates phosphorylase kinase.[11] Phosphorylated phosphorylase kinase phosphorylates phosphorylase.

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