Question

You are a single molecule of glucose. Describe ALL of the anatomy that you would see, including transporters and pumps, as you travel from the afferent arteriole all the way to your reabsorption back into the kidney tissues. Second, describe all of the anatomy that you would see if your human had taken a sodium/glucose co-transport inhibitor

Answer 1

Glucose is reabsorbed back into the blood from the glomerular filtrate in the proximal convoluted tubule. The glucose present in the affarent arteriole gets filtered at the Bowman's capsule. The reabsorption of glucose takes place by two mechanisms,

• Carrier mediated sodium glucose cotransport in the apical membrane
• Facilitated diffusion and active sodium extrusion

SGLT2 is present in the early proximal tubal cell and SGLT1 is present in the late proximal tubal cell.

If the person has taken sodium glucose cotransporter inhibitor, there will only be facilitated diffusion of glucose.