Question

(B) The figure below shows the production of HCL in a parietal cell. A patient took a drug that inhibits carbonic anhydrase. (i) What is the likely effect of this carbonic anhydrase inhibitor on the HCl secretion from the parietal cell? Provide a schematic explanation on its predicted effect against H+ secretion. (Not more than 50 words.)

Answer 1

Answer. As no figure has been provided, thus, answering on my own.

Under the action of gastrin, histamine and acetylcholine HCl is produced by the parietal cells of the stomach that helps in creating acidic medium in the stomach.

Beside this, the dissociation of water in the parietal cells increases H ion concentration, this increased ion concentration is used by carbonic anhydrase enzyme to form carbonic acid utilising bicarbonate ions.

If carbonic anhydrase will be inhibited then there will be no carbonic acid. Carbonic acid helps in the transport of CO2 in the body and helps in maintaining partial pressure for inspiration and expiration. Along with this, increased H+ concentration in parietal cells will made pH more acidic then to what it was initially.