Mary presents with symptoms of hyperthyroidism.
1. What would some of those symptoms be?
2. Her blood panel shows elevated T3, elevated TSH, and depressed TRH. Which gland is not working correctly?
3. Based on this, are there any other hormones that might also be elevated?
4. For TSH, TRH, and T3, does each bind an internal or external receptor?
1- Thyroid hormone increases the basal metabolic rate. Therefore in hyperthyroidism there is unexpected weight loss, increased sweating, heat intolerance, palpitations. These are the most common symptoms.of hyperthyroidism.
2- Defect is in the pituitary gland because there is increased TSH levels in pituitary despite of decreased TRH levels from hypothalamus. This means pituitary is out of feedback inhibition from increased thyroid hormones from thyroid gland. Normally TSH from pituitary is secreted in response to TRH.
3- As there is defect in pituitary (pituitary is secreting excessive hormone), other hormones of pituitary such as LH, FSH, ACTH, GH and prolactin can also be increased.
4- TSH and TRH binds to cell membrane receptors (G- protein coupled receptor) whereas T3 binds to Nuclear receptor.
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