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At the Neuromuscular Junction, Acetylcholine (ACh) binds to a(n) ______ Receptor Site, which opens up a(n)...

At the Neuromuscular Junction, Acetylcholine (ACh) binds to a(n) ______ Receptor Site, which opens up a(n) _______ Channel.

A. Nicotinic ACh ; ligand-gated Na+

B. Nicotinic ACh ; voltage-gated Na+

C. Muscarinic ACh ; ligand-gated Na+

D. Muscarinic ACh ; voltage-gated Na+

E. Adrenergic ; ligand-gated Na+

Science   Anatomy-And-Physiology   
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Answer #1

Answer:

Option A (Nicotinic Ach; ligand gated Na+)

Explanation: Acetylcholine is a neurotransmitter which gets released at the neuromuscular junction in response to the response of a muscle to contract. At the junction after their release, the chemical acetylcholine is received by the receptors named; Nicotinic receptors. The receptors are called so because they bear large proteins named nicotine within the muscles fibers.

Also they have the potential of binding to the membrane of the target cell just like the primary neurotransmitter namely; acetylcholine.

In response to the information received by the neurotransmitter Ach; the receptors are known to open up the ligand gated ion channels directly and they are not likely to make use of any secondary messenger like Ca2+ ions. Henceforth, the nicotinic Ach receptors are also known as cholinergic ionotropic receptors.

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