Question

which cell has a large nucleus that fills most of the cell?

Answer 1

Lymphocytes.

Lymphocytes are one of several different types of white blood cells, with a very large nucleus, rich in DNA, and a small amount of clear cytoplasm, which is found in the blood. It produces antibodies and is important in defence against disease.. The bone marrow constantly produces cells that will become lymphocytes. Some will enter the bloodstream, but most will move through the lymphatic system

Lymphocytes vary widely in size. Small lymphocytes are 7 to 10 µm in diameter, and large lymphocytes are approximately 14 to 20 µm in diameter, although intermediate sizes may be encountered.