Staphylococcus aureus strains become pencillin-resistant shorlty after the antibiotic emergence by the mechanism of hydrolysing the β-lactam bondwhich is crtical for pencillin and other β-lactam antibiotics which destroys the antobacterial activity of the drug.
It also inhibit β-lactam antibiotics by inhibiting the proteins called penicillin-binding proteins. PBPs are important for peptidoglycan synthesis. It eveade the antibiotic activity by expressing the foreign PBP, PBP2a which is resistant to β-lactam antibiotics but can function like host PBP.
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