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what are the two sudden change from penicillin susceptibility to penicillin resistance from the staphylococcus aureus?

what are the two sudden change from penicillin susceptibility to penicillin resistance from the staphylococcus aureus?
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Answer #1

Staphylococcus aureus strains become pencillin-resistant shorlty after the antibiotic emergence by the mechanism of hydrolysing the β-lactam bondwhich is crtical for pencillin and other β-lactam antibiotics which destroys the antobacterial activity of the drug.

It also inhibit β-lactam antibiotics by inhibiting the proteins called penicillin-binding proteins. PBPs are important for peptidoglycan synthesis. It eveade the antibiotic activity by expressing the foreign PBP, PBP2a which is resistant to β-lactam antibiotics but can function like host PBP.

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