Question

Which of the following mechanisms in a liver cell contribute to ketoacidosis in type I diabetics?...

Which of the following mechanisms in a liver cell contribute to ketoacidosis in type I diabetics?

Increased citric acid cycle activity leading to decreased levels of oxaloacetate
All of the mechanisms contribute to ketoacidosis.
Reduction in the rate of β-oxidation reactions
Decrease in insulin inhibition of fatty acid oxidation
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Answer #1

B) All of the mechanisms contribute to ketoacidosis.

Explanation: Diabetic ketoacidosis occurs when there is elevated glucose level due to high level of glucagon and low level of insulin. As a result a low level of insulin, Activation of lipolysis in adipose tissue results in release of increased amounts of free-fatty acids (FFA) into plasma, which are taken up by the liver. these excessive free fatty aids are converted into the ketone bodies.

This also inhibits the fatty acid oxidation

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