Which of the following DOES NOT contribute to the sensitivity of neurons to toxicants?
a. |
Reliance upon mitochondrial generation of ATP for energy combined with limited capacity to store glycogen |
|
b. |
Limited ability to regenerate new neurons after damage |
|
c. |
Location exclusively in the peripheral nervous system |
|
d. |
Large surface area relative to mass |
Answer:
c. Location exclusively in Peripheral Nervous System.
This is because it's location can also be well traced to Central Nervous System though being protected by Blood-Brain-Barrier. Other options can contribute because: Neurons do rely on mitchondrial generation of ATP and infact healthy neurons do not store glycogen. But degenerating neurons do accumulate glycogen. Moreover, they have limited ability to regenerate and large surface area to mass ratio which can contribute to toxicity.
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