Question

A patient is prescribed a drug called spironolone. This drug blocks the action of aldosterone on the distal tubule and collecting duct. When taking the drug, how will the patient's urine be different from the urine produced before taking the medicine?

Select one:

a. When taking the drug, the urine will have more Na⁺, more K⁺, more Cl^-, and more water.

b. When taking the drug, the urine will have more Na⁺, less K⁺, more Cl^-, and more water.

c. When taking the drug, the urine will have less Na⁺, less K⁺, less Cl^-, and less water.

d. When taking the drug, the urine will have less Na⁺, more K⁺, less Cl^-, and more water.

e. When taking the drug, the urine will have less Na⁺, more K⁺, less Cl^-, and less water.

Answer 1

Option b is the correct answer as the function of aldosterone is to cause the retention of sodium, chloride and water . It caus excretion of pottasium through urine . So when aldosterone is blocked by the spironole it will lead to increase in pottasium in ECF and in less in urine . Sodium, chloride and water excretion increase

Option a is wrong as less pottasium is excreted

Option c is wrong as more water is excreted

Option d is wrong as more chloride is excreted

Option e is wrong as more water is excreted

:)