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Explain how the blocking of angiotensin-converting enzyme (ACE) activity with a drug affects the regulation of...

Explain how the blocking of angiotensin-converting enzyme (ACE) activity with a drug affects the regulation of sodium reabsorption in response to an intake of a low sodium diet.

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The angiotensin converting enzyme (ACE) is secreted from the surface of lungs, which functions to catalyze the conversion of angiotensin-I to active vasoconstrictor angiotensin-II, and stimulates adrenal cortex to release aldosterone hormone to increase sodium reabsorption.

The administration of a drug blocks the ACE activity, then angiotensin-I would not be converted into active angiotensin-II, which results in inhibition of aldosterone hormone secretion, and as a consequence the sodium ions reabsorption in distal convulated tubule (DCT) would be significantly decreased.

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