Question

A genetic defect that prevents the production of Defensins would most likely increase the susceptibility to which of the following pathogens. (Select all that apply and explain.

	A.	Influenza Virus
	B.	Malaria parasite
	C.	E coli
	D.	Rhinovirus
	E.	mycobacteria

Answer 1

C. Ecoli

E. Mycobacteria.

Defensins is peptides made up of about 30 amino acids. produced by cells of the innate immune system and epithelial cells, Defensins are effective against Gram-negative and Gram-positive bacteria including mycobacteria and are active both intra- and extracellularly. E.coli is a gram negative bacteria.Defensins acts as phagocytic cells against intracellular pathogens, such as Mycobacteria tuberculosis, by an oxygen-independent mechanism