A fully developed atherosclerotic lesion is called
Atheroma.
Unlike fatty streaks,Atheroma are selective in
different geographic locations and races and are seen in advanced
age.
Atheroma lesions may develop from progression of early
lesion of the atherosclerosis.
Most often and most severly affected is the abdominal
aorta,though smaller lesion may be seen in descending thoracic
aorta and aortic arch.
The major branches of the aorta around the ostia are
often severly involved,especially yhe
iliac,femoral,carotid,coronary and cereberal
arteries.
The process of atherogenesis are endothelial
dysfunction,Formation of lipid layer,migration of leukocytesand
smooth muscle cells into the cell wall,foam cell
formation,degradation of extracellulae matrix.