Question

A 13-year-old girl is evaluates because she presents stunted growth as well as recurrent pathological bone fractures. Her height is a little more than 1.10 m, and she weights 21 kg. She presents deformities in her legs and has had kidney stones in the past. X-rays show the deformities, bone decalcification and nephrocalcinosis. Lab test have the following results.

Na+	139 mEq/L
K+	3.2 mEq/L
Ca2+	9.0 mg/dL
Cl-	114mEq/L
Phosphate	1.9 mg/dL
BUN	10 mg/dL
Total proteins in urine	6.5g/dL
Urine specific gravity	1.010
pH (urine)	7
pH (blood)	7.3
PCO2	27 mm Hg
GFR	56 mL/minute/1.73 m2

Can you place in which part of the nephron the injury took place? How do you explain the hypophosphatemia?

Answer 1

The injury take place medullary sponge kidney part which is seen through x ray I'n this condition calcium level In kidney increased localized increase observed in renal tract and there is formation of renal tuberculosis may be the cause are vary or different like in this conditions other causes or nephrocalcinosis are glycol toxicity uses of certain medications like amphoteriCin etc kidney infection etc

Hypophosphatemia is disorder related with electrolyte disorders In which low level of phosphate in blood cause hypophosphatemia

Symptoms are loss of appetite dyspnea general body weakness

Hypophosphatemia is caused when serum concentrations phosphate is lower than 2.5mg/dl other symptoms is seizure heart failure etc