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What are the Calculations of plasma pH using pCO2 and [HCO3-] ?

What are the Calculations of plasma pH using pCO2 and [HCO3-] ?

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Answer #1

Plasma pH can be calculated by using pCO2 and [HCO3-] -

The Henderson Hesselbalch equation - This equation represents the solution resists the alteration in pH,when small amount of strong acid or base is added to establish the equilibrium between the weak acid and its conjugate base.

CO2 + H2O ----- H2CO3 -----H+ + HCO3-

pH =pK + log [HCO3-/H2CO3]

pK = ionization constant =6

pH =6.1+ log [HCO3-/H2CO3]

pH = 6.1 + log [HCO3-/ 0.03 X pCO2]

(HCO3- is regulated by kideny and pCO2 is regulated by lungs )

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