Question

Describe five phenomena associated with increased local cortical metabolism

Answer 1

The cortical metabolism is important for proper functioning of the brain cells. The cortical metabolism may be dysregulated in various neuro degenerative conditions.
The five phenomena associated with increased cortical metabolism are :

1. increased demand of oxygen by cortical cells.
2. increased glucose uptake

3. increased lipid metabolism

4. increased mitochondrial functioning

5. increased excitatory postsynaptic potential

6. Increased oxidative stress

7. increased neuronal degeneration

Increased cortical metabolic activity has been seen in several diseases such as Alzeihmer's disease, schizophrenia, parkinson, Huntington disease, brain epilepsy.