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Why agonist is able to activate the receptor and make them undergo conformational change?

Why agonist is able to activate the receptor and make them undergo conformational change?
Science   Anatomy-And-Physiology   
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Answer #1

Agonist is defined as chemical that binds to receptor that stimulate the reaction and biological response

Many receptors are of cellular component. Agonist mimic the natural ligand when natural ligand is not available or its lacking in the body. After mimicking the ligand, it binds to receptor just like lock and key and activate the receptor through chemical changes and proceeds the biological actions.

Agonist bind in step by step and These agonist change the shape of micro molecules of the receptor as natural ligand(hormone or neurotransmitter ) while to binding to receptor member it transmit signal or bring directly change in the cell which in turn. They are able to do activation and brings changes in the receptor because it follows the same pathways as natural ligand follows but they are synthetic in nature.

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