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SA node physiology: Compare and contrast these two conditions on heart rate: (1) decrease permeability of...

SA node physiology:

Compare and contrast these two conditions on heart rate: (1) decrease permeability of Funny-Na+ channels and (2) partially blocks SA node Voltage gated- K+ channels

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Answer #1

Decreased permeability of Funny-Na+ channels

Partially blockade of SA node Voltage gated- K+ channels
  • It leads to activation of cAMP and hyperpolarization
  • It leads to depolarization and prolongation of action potential
  • The channels revert to resting state.
  • There is repetitive firing of neurons
  • There is responsiveness towards neurotransmitter.
  • There is increased transmitter release
  • There is no glandular activity
  • There is an increased endocrine activity

The inward current mediated partly by potassium and partly by sodium is important for pacemaker cells (hyperpolarized cells).
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