Question

1.  A clinical lab test to identify which specific allergen is causing the allergic reaction in a patient is called: (name the lab test):_________________________________.

2. HLA classes can be distinguished on the basis of:

                        1.         _____________________________________________ .

            

                        2.         _____________________________________________.

3. _____________________________________________ .

4. _____________________________________________ .

Answer 1

Answer 1:

1. Radioallergosorbent test
   • An allergic reaction is IgE mediated hypersensitivity reaction ( type I hypersensitivity)
   • Therefore, if the body is exposed to an allergen, a specific IgE will be produced against it.
   • This test ( also called RAST) identifies specific IgE against the allergen
2. HLA classes are distinguished on the basis of structure and function of the gene product
   • Example -
     • HLA -1 presents endogenous peptides to corresponding into CD+8 T cells
     • HLA - II presents exogenous peptides to CD-4+T cells
     • HLA class III encodes components of the complement system