Question

Ziconotide is a drug that blocks calcium channels on nociceptive neurons. Which is TRUE? a. It...

Ziconotide is a drug that blocks calcium channels on nociceptive neurons. Which is TRUE?

a. It is used to treat severe and chronic pain.

b. It is used to restore balance.

c. It is an analgesic.

d. It is used to treat tinnitus or “ ringing in the ears.”

e. More than one above

Science   Anatomy-And-Physiology   
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Answer #1

Correct answer:

Option e - More than one above

  • it is used to treat severe and chronic pain
  • it is therefore an analgesic

Explanation:

  1. It blocks the N-type of calcium channel present on the afferent nerve of the dorsal horn in the spinal cord
  2. It is a conopeptide, it is not an opioid
  3. It is used for chronic pain given intrathecally
  4. Initial dose is 2.4 mcg/day - increase by 2.4 mcg/day at intervals of 2-3 times a week ( no to cross 19.2 mcg/day by the 21 day)
  5. Severe psychiatric and neurological impairment occurs with the drug

Incorrect answer:

b - restore balance - wrong - this drug can cause ataxia (loss of balance) in 14% of patients

d - Use to treat tinnitus - wrong - In a randomized placebo-controlled trial of 39 patients where ziconotide was slowly titrated in 220 subjects, tinnitus was one of the observed side effects.

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