Question

Following absorption, which of the following nutrients enters systemic blood circulation without first passing through the liver?

Group of answer choices

Monosaccharides

Triglycerides

Amino acids

Water-soluble vitamins

None of the above. All newly absorbed nutrients pass through the liver before entering systemic blood circulation.

Answer 1

Correct answer - Triglyceride

Explanation:

• Bile emulsifies fat in the diet, making it easier for lipase enzymes to act on them
• The lipase enzymes convert triglycerides to fatty acids and mono/diglycerides.
• They enter the enterocytes where they are re-esterified to triglycerides.
• the triglyceride combines with phospholipids, cholesterol ester, apolipoprotein B48 and forms chylomicrons
• These chylomicrons enter the lacteal of the small intestine.
• the lacteal is a capillary of the lymphatic system
• These lacteal combine to form lymphatic vessels and these vessels drain the lymph into the thoracic duct.
• From the thoracic duct, the lymph enters the left subclavian artery.
• They don't enter the liver. therefore no first pass metabolism

Incorrect answer:

Monosaccharides, Amino acids, Water soluble vitamins enter the portal circulation and enter the liver.