Question

How can you make a nerve less sensitive

Answer 1

Neuronal Cells become less sensitive to stimulus by following methods:

1. Hyperpolarisation- Hyperpolarisation of the cell leads to resting membrane potential becoming more negative. This increases the threshold required for the depolarisation of the cell. This is usually achieved by action of inhibitory neurotransmitters on these cells which usually leads to opening of chloride channels and movement of Cl- ions inside the cell making inside of the cell more negative comapred to the outside.

2. Blocking receptors of excitatory neurotransmitters-

Blocking receptors of excitatory neurotransmitters leads to inhibition of excitation of neurons and cells become less sensitive.