Question

based on skeletal system name one of the cell types affected by postmenopausal osteoporosis?

Answer 1

Estrogen plays a central role in the control of bone strength, and its loss at menopause causes osteoporosis in millions of women. In healthy individuals, bone mass is maintained by the balanced activity of bone-forming osteoblasts and bone-resorbing osteoclasts.

Osteoporosis, at the outset, is a disease of increased bone turnover in which the bone-resorbing activity of osteoclasts outpaces the bone-forming activity of osteoblasts, leading to loss of predominantly trabecular bone. Both of these cell types are reported to respond to estrogen. However, many studies suggest that bone's response to estrogen withdrawal is at least in part mediated by a network of inflammatory and osteoclastogenic cytokines including TNFα and IL-1, released by stromal/osteoblast lineage cells and T cells . Thus, the critical estrogen target cell has been a matter of considerable debate.