Question

In the intestines, cAMP results in the opening of chloride channels and the secretion of chloride ions into the intestinal lumen. In these intestinal cells, the cholera toxin, released by the Vibrio cholerae bacterium, inhibits GTPase activity in the G protein involved in the above physiology. Therefore, the result would be:

a) prolonged stimulation of adenylyl cyclase, and excess secretion of chloride ions
b) reduced stimulation of adenylyl cyclase, and less secretion of chloride ions

Answer 1