Question

what are 3 morphological changes in the brain tissue in Alzheimer disease???

Answer 1

Alzheimer's disease is a progressive disorder that causes degeneration of brain cells .

Morphological Changes in Brain Associated with Alzheimers are-

1.positive lesions - amyloid plaques and cerebral amyloid angiopathy

Amyloid Plaques:they are accumulations of insoluble and Hard beta amyloid proteins that clump together between the nerve cells of Brain.

Cerebral Amyloid Angiopathy:This is the build up of amyloid on the walls of the arteries in the brain.

2.Neurofibrillary tangles:These are the aggregates of hyperphosphorylated tau protein.

3.Glial Responses:Glial Cells astrocytes and activated microglia decorate amyloid plaques in the cortex.