Question

Briefly describe how NMDA and AMPA receptors work together to produce a postsynaptic response, and how NMDARs are involved in coincidence detection .

Answer 1

NMDA and AMPA/kainate receptors. (A)

NMDA and the AMPA plays a vital role in postsynaptic response both of these have a gutamate binding site and mg+ binding pores and if the response is to be blocked the mg2+ ion channels helps in blocking of receptors. Ca2+ has a major role in the activation and mg2+ has a major role in blocking the response. The positive charge flow into it when the glycine and glutamate bind to the receptors and activate it there bay leading to influx of positive ions and bringing about a postsynaptic response

NMDARs involvement in coincidence detection

They are an important substance required for coincidence detection , memory and learning in CNS. And synaptic plasticity. It works by voltage gated mg2+ block of NMDARs which allow the function of the coincidence detection that is the ,Hebbian coincidence detector