Question

I am a little confused about cellular changes (atrophy, hypertrophy, etc). According to my study guide (Gould's pathophysiology for Health professions, the thyroid gland's response to hypersecretion of thyroid-stimulating hormone is metaplasia, dysplasia and neoplasia. While this makes sense, why does the liver's response to prolonged drug intoxication result in hyperplasia and not the same result as the thyroid? I have the answers because they're in the back of the book, but what I don't understand is why.

Answer 1

Answer :)

Metplasia is the condition where cells changed their nature. Dysplasia occurs when cells develop abnormally because they get new changes; this may cause cancer. In neoplasia, cells grow abnormally due to they become cancer cells.

Hyperplasia of liver is different from above concepts. Here cells of liver are normal and controlled but due to long toxic exposure, the liver cells grow enormously for the proper functioning of liver. Hyperplasia can undergo cancer condition, if intoxication does not stop.

Liver have regenerative property and it is the main reason why liver goes under hyperplasia in intoxication condition. Thyroid gland does not have, over secretion of thyroid hormone causes changes in its cells genetics.

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