Question

The misfolded protein present in Parkinson's disease is:

Select one:

a. alpha-synuclein

b. beta-amyloid

c. tau proteins

d. prion proteins

\e. superoxide dismutase

Answer 1

ANSWER- OPTION A- ALPHA- SYNUCLEIN

EXPLANATION- Alpha synuclein is a pre synpatic neuronal protein that is linked genetically and neuropathologocally to parkinson's disease.  

Alpha synuclein is normally a wavy like structured proetin, and in the parkinson's disease, this protein misfolds forming toxic clump or aggregate. During this process, these early aggregartions are found to be very reactive and are belived to cause damage to cellular components.

Other options-

Beta amyloid and tau proteins is involved in Alzheimer's disease. (it is also due to protein misfoldings)

Superoxide dismutase is an enzyme that breaks harmful oxygen molecules which might cause cellular damage.

Prion proteins-these are proetins which get altered and abormal proteins are formed in the brain, these cause prion disease which includes- creutzfeldt- jakob disease (CJD), fatal familial insomnia.