Question

what are some of the functions of inhibitory synapses? considering this, what symptoms would you expect from the disease tetanus, and why?

Answer 1

The functions of inhibitory neurotransmitters are inhibiting the generation of action potential in post-synaptic neuron. These includes GABA (Gamma amino butyric acid) and glycine.

Mechanism of tetanus toxin -

After effected with tetanus, tetanus toxin transported in retrograde way to the GABA and glycine producing inhibitory neuron terminals.

This toxin prevents the release of GABA and glycine from pre-synaptic neuron. This leads to exaggerated excitation in post synaptic neuron terminals.

Symptoms of tetanus -

1. Trismus-lock jaw followed by muscle pain and difficulty in swallowing.

2. Deep tendon reflexes are exaggerated.

3. This leads to descending spastic paralysis. The paralysis due to exaggerated excitation is called spastic paralysis.