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Explain the difference between Exogenous and Endogenous antigens presented by MHC class I and class II

Explain the difference between Exogenous and Endogenous antigens presented by MHC class I and class II

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Exogenous antigen presentation- when the exogenous antigen enters the body it undergoes endocytosis by some antigen presenting cells such as macrophages, dendritic cells, or B cells. After endocytosis the antigen is degraded into peptide fragments in endoplasmic reticulum and attached with MHC 2 molecule. This complex of MHC and peptide is then transported to cell surface which is then presented to helper T-cell.

Endogenous antigen presentation- Antigen produced in host cell either it be viral cell protein or some abnormal protein made by cancer cells. All the nucleated cells in body express MHC 1 molecule so these endogenous antigens after degradation into peptide are associated with MHC 1 molecule and this complex is transferred to cell surface which is then presented to CD8 t cell (cytotoxic t cell).

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