Question

For each of the following scenarios, state whether it is a pharmacodynamic or pharmacokinetic interaction.

a)Drug A acts as an IL-12 receptor agonist. A downstream event of IL-12 signaling is STAT4 activation by JAK2 phosphorylation. Drug B binds to

JAK2 and prevents STAT4 phosphorylation, thus preventing STAT4 activation.

b)Drug A is metabolized by CYP3A4. Drug B induces CYP3A4.

c)Drug A and Drug B are combined in an IV bag. Mixing the drugs causes the ionization state of each drug to change. Now A gets absorbed less in the intestines and B gets absorbed more in the intestines.

Answer 1

a)	Pharmacodynamic	Pharmacodynamics is the study of the biochemical, physiologic, and molecular effects of drugs on the body and involves receptor binding.
b)	Pharmacokinetic	Pharmacokinetics refers to the movement of drug into, though, and out of the body,the time course of its absorption, bioavailability, distribution, metabolism, and excretion. Drug metabolism is the chemical alteration of a drug by the body.
c)	Pharmacokinetic	Pharmacokinetics refers to the movement of drug into, though, and out of the body, the time course of its absorption, bioavailability, distribution, metabolism, and excretion. Drug absorption is the movement of a drug from its site of application into the bloodstream