Tagamet and Zantac reduce gastric acid secretion by acting on which receptor type and on which cells?
CCK1; parietal cells |
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Histamine 2; parietal cells |
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Gastrin; G-cells |
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CCK2; parietal cells |
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Histamine 2; Enterochromaffin like cells |
Ans:- b) histamin 2 , parietal cell
Tagamet (cimetidine) and Zantac (ranitidine hydrochloride) are histamine receptor antagonists used to treat and prevent ulcers. Tagamet is also used to treat conditions that cause the stomach to produce too much acid, and to treat gastroesophageal reflux disease (GERD).
Mechanism of action
. Ranitidine is a competitive, reversible inhibitor of the action of histamine at the histamine H2 receptors found in gastric parietal cells. This results in decreased gastric acid secretion and gastric volume, and reduced hydrogen ion concentration.
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