The force of contraction of the cardiac muscle is affected by:
A- muscle fibre length at start of contraction
B- contractility of heart
C- the end diastolic volume
D- amount of blood entering heart
E- All of above
Dear Student,
The force of contractility of cardiac muscles depends on many factors like
* Activation of sympathetic system
*Sudden increase in afterload
*Bowditch effect- Inotropy is stimulated by an increased heart rate
*Rise in calcium levels
*Drugs (positive inotropic drugs)
*Anrep effect- increase in afterload increases contractility
*Starlings law - increase in pre-load causes increased force of contraction.
*Amount of blood entering the heart, etc
So the answer is all of the above.
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