Question

If a man had high levels of gonadotropin-releasing hormone, what might be the
explanation?
A. he is missing his posterior pituitary gland
B. he will be releasing little FSH and LH into circulation as a result
C. he may be using an anabolic steroid drug
D. he may have recently undergone testes removal (castration)

Answer 1

Answer:

D. he may have recently undergone testes removal (castration)

Explanation: Gonadotropin releasing hormone is produced by the hypothalamus. Its secretion is under the negative feedback control of FSH, LH and testicular hormones.

When testes are removed, the negative feedback ihibitory signals to hypothalamus is lost, resulting increased production and release of the GnRH. This in turn increases the release of more FSH and LH in the blood.

Regarding option C, if the person was using anabolic steroid drug, then his GnRH level would be low.