Question

We studied the adrenal glands and learned about Addison's disease and Cushing's syndrome. Using your knowledge about the tropic hormones that are at the heart each of these diseases explain what happened to normal levels of each in each disease. A full credit answer will also explain the normal function of this endocrine axis.

Answer 1

Addison disease and cushing's syndrome is the endocrine malfucntion disease caused due to the hormone imbalances of adrenal gland i.e. cortisol and aldosterone.

In addison disease condition,low level of aldosterone and cortisol hormones get produced through adrenal gland ,it occurs due to damage of the adrenal gland due to autoimmune disease.

In cushing syndrome,high level of the cortisol and Adrenocorticotropic hormone (ACTH) has been observed due tumor like condition or glucocorticoid therapy.

In normal condition - elevated Cortisol released from the adrenal gland negatively feedback the production fo ACTH and CRH release.