Question

Forskolin is a drug that activates adenylyl cyclase. You would expect this drug to: a. increase...

Forskolin is a drug that activates adenylyl cyclase. You would expect this drug to:

a. increase heart rate

b. decrease heart rate

c. increase the force of cardiomyocyte contraction

d. decrease the rate at which the pacemaker potential depolarizes the cell

e. a and c are correct.

Science   Anatomy-And-Physiology   
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Answer #1

Adenylyl cyclase is a intracellular enzyme participates in intracellular signaling pathway that produce a major response. It activates an important intracellular second messenger that is adenosine 3′,5′-cyclic monophosphate (cAMP). This second messenger influences ionotropic and chronotropic effects of heart

Up on stimulation of Adenylyl cyclase by Forskolin, it catalyses the conversion of ATP to cAMP occur in the cardiac cell and increase the second messenger cAMP concentration in the cell. Increased cAMP concentration produce positive ionotropic (increased force of contraction) and Positive chronotropic (increased heart rate) effects

Thus answer is e. a and c are correct.

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