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Porin molecules: - What do porin molecules allow to cross the cell membrane? The human aquaporin...

Porin molecules:

- What do porin molecules allow to cross the cell membrane? The human aquaporin (AQP1) has 4 monomers each containing 269 amino acids organized into which secondary structures?

- Explain how the hormone vasopressin (ADH) allows the kidney to reabsorb water using the aquaporin-2 water pore. What affect does this have on blood pressure?

Science   Anatomy-And-Physiology   
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Answer #1

Porins are some beta barrel proteins that acts as channels through different cell membranes and allow to pass various kind of molecules via passive diffusion. Some specific ions as Na+, K+ and Cl- besides water molecules can pass through these channel proteins.

According to modern study it has been found that monomers to aquaporins (AQP1) of human beings are organised as tetrameric helices and a central pore that allows H2O (water) molecules along with other ionic species such as Cs+ and K+ through them.

Hormone vassopresin or Antidiuretic hormone (ADH) is released from posterior lobe of pituitary gland when the plasma volume of blood decreased due to excessive loss of water in the body. Hence, ADH increases water absorption in the loop of Henle's in the nephrons of kidney. Thus, the pressure of blood gets increase due the high concentration of water in the blood plasma.

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